Infected people sometimes secreted and transmitted the virus to another person directly or indirectly (by hand) contact, mainly saliva. Due to the sensitivity of the virus are expressed on external factors, with consequent loss of infectivity outside the human body, for the transmission of the virus needed was a close and direct contact, usually kissing ("kissing disease"). Although the virus is present in epithelial cells of the cervix, in seminal fluid and urethral swabs and urine, to date no clear evidence of transmission of EBV through sexual contact or urine. Transmission of the virus through blood transfusions and bone marrow transplantation can be reported as a rare occurrence.
The diagnosis of infectious mononucleosis is based on the appearance of clinical signs and symptoms (fever, swollen glands, tonsillitis, enlarged spleen) and the results of laboratory tests (increased number of white blood cells, atypical lymphocytes, pathological aminotrasferaza), and to confirm the diagnosis performed by serological tests (nonspecific heterofilna and EBV-specific antibodies).
Treatment consists of lowering a high temperature and at rest. In patients with symptoms of obstruction of the respiratory system, resulting from islands lining the throat and tonsils, applied corticosteroids. Also, it is recommended to use corticosteroids in patients with significant thrombocytopenia and hemolytic anemia.